Low Dose Naltrexone (LDN)
The treatment your doctor wasn’t taught exists. Your immune system is stuck in overdrive. Chronic inflammation, brain fog, fatigue that sleep doesn’t fix. Traditional medicine calls it “stress” and sends you home. Low-dose Naltrexone works at the microdose level to calm the immune response that’s burning you out. Off-label. Effective. Overlooked by mainstream medicine.
Immune modulation, not suppression. LDN regulates an overactive immune system. It doesn’t weaken your defenses.
No labs required. Start based on symptoms and goals. Optional testing available, but not required.
Builds over time. Some benefits in 1 to 2 weeks. Full effects develop over 4 to 12 weeks.
Safety Information
HSA/FSA Eligible ✓
Transparent LDN pricing
One price. Everything included. No hidden fees, ever.
Most Popular
Quarterly
$69/mo
Save $240/year
$267 $207 billed quarterly.
Monthly
$89/mo
No long-term commitment
$178 to start, then $89/mo.
All subscription plans auto-renew. Cancel anytime.
Everything you need
What’s included with low-dose naltrexone
Safe, effective treatment shipped directly to your door.
Your protocol
What to Expect:
Clearer thinking and fewer “lost” afternoons within 1 to 2 weeks
Steadier mood and less emotional reactivity within 2 to 4 weeks
Persistent aches and inflammatory flares calm over 4 to 12 weeks
Sleep that leaves you rested, not just unconscious
Includes:
4.5mg flex tabs (#30), divisible into quarters for dose titration†
Personalized dosing guidance based on your sensitivity
Provider consultations for monitoring and adjustment
Free shipping
†Most patients start at 0.5 to 1.5mg and titrate up to 1.5 to 4.5mg based on tolerance and goals. We customize your protocol, not hand you a standard dose and hope for the best.
See the difference
How our LDN compares
Mainstream medicine ignores LDN. When they do prescribe it, they often get the dosing wrong. We specialize in what others overlook.
Product Comparison
Industry Standard
Transparent pricing, no hidden fees
24-hour response guarantee
Microdosing tailored to your sensitivity
Providers experienced in immune modulation
Ongoing dose adjustment and monitoring
Flex tabs for precise titration
Free follow-up consultations
Licensed physician oversight
What mainstream medicine overlooks
Why your doctor won’t prescribe it.
This treatment isn’t new. Functional medicine practitioners have used it for chronic inflammation and immune dysfunction for decades. The research exists. The clinical experience exists. But mainstream medicine moves slowly when there’s no pharmaceutical profit involved.
The off-label problem
LDN is FDA-approved only at high doses (50mg+) for addiction. At low doses, it triggers your body’s natural healing mechanisms instead of blocking them. But “off-label” scares most doctors. They weren’t taught about it. Insurance won’t cover it. So they pretend it doesn’t exist.
How it restores balance
LDN briefly blocks opioid receptors for a few hours. Your body responds by producing more endorphins. Those endorphins then regulate immune cells, calm overactive inflammation, and quiet the glial cells driving chronic pain and fatigue. You’re not masking symptoms. You’re fixing the signaling.
Simple. Fast. No runaround.
How LDN treatments work here
Three steps. Same-day appointments available.‡
1 Free Consult
Schedule a video call with one of our providers. We’ll discuss your symptoms, review your health history, and determine if treatment is right for you.
2 Treatment Plan
We finalize your protocol with transparent pricing. You’ll know exactly what you’re getting and what it costs before you commit to anything.
3 Ship Meds
Your medication ships discreetly with all supplies included. Ongoing provider appointments monitor your progress and adjust your protocol as needed.
‡Subject to provider availability
What happens when inflammation finally backs off
Specific outcomes. Realistic timelines. Based on what patients report.
Energy & clarity
Brain fog comes from neuroinflammation. LDN quiets the overactive signaling. Most patients notice sharper thinking within 1 to 2 weeks.
Mood stability
Endorphins regulate emotional resilience, not just “feeling good.” LDN boosts your natural production. Better stress tolerance within 2 to 4 weeks.
Pain that responds
Chronic aches that don’t respond to typical treatments often stem from an immune system that won’t calm down. LDN addresses the source. Benefits build over 4 to 12 weeks.
Sleep that restores
Vivid dreams are common in the first 1 to 2 weeks. Then sleep gets deeper. Most patients notice more restorative sleep within 2 to 4 weeks. Better sleep means better recovery means better everything.
Immune balance
LDN doesn’t suppress your immune system. It teaches an overactive one to stand down. Your defenses stay intact while inflammation calms. Benefits build over 4 to 12 weeks.
Protocol synergy
Chronic inflammation undermines results from TRT, peptides, and longevity protocols. LDN clears the interference. Many patients stack it.
Real patients. Real Results.
Why men choose TestDepot
Hear from men who’ve been where you are.
“These people are great. Easy to work with, labs, questions, payment, and consultations. I looked around and read a lot of reviews before I chose this site/group and I can not be happier with the service!”
– Robert Powell
“This has to be one of the easiest processes I’ve ever used, I’ve actually referred a few friends since I started using this.”
– Louis Rickoff
FAQ
LDN questions answered
The questions most men ask before starting.
What is Low-Dose Naltrexone, and how is it different from regular naltrexone?
Naltrexone at standard doses (50mg+) blocks opioid receptors continuously for addiction treatment. Low-Dose Naltrexone (0.5 to 4.5mg) briefly blocks receptors for a few hours, triggering your body to produce more endorphins. Those endorphins then regulate immune function, reduce inflammation, and support pain management. Same drug, completely different mechanism at different doses.
How does LDN work in the body?
Three mechanisms. First, brief receptor blockade triggers increased endorphin production, improving mood and immune regulation. Second, LDN quiets overactive microglial cells linked to chronic pain, fatigue, and brain fog. Third, LDN modulates immune signaling, balancing an overactive response without suppressing your ability to fight real threats.
What results can I expect from LDN?
Most patients notice improved energy and reduced brain fog within 1 to 2 weeks. Better mood typically appears within 2 to 4 weeks. Improvements in inflammation and pain develop over 4 to 12 weeks. The treatment is subtle but cumulative. Benefits build with consistent use.
How do I take LDN and how often?
Once daily, typically at bedtime. We start with lower doses (0.5 to 1.5mg) and titrate to your optimal range, usually 1.5 to 4.5mg. Our flex tabs divide into quarters for precise dosing. This isn’t one-size-fits-all medicine.
What are the potential side effects of LDN?
LDN is generally well tolerated. Common adjustment effects include vivid dreams or mild sleep disruption during the first 1 to 2 weeks. Some patients experience mild headache or temporary restlessness. Most side effects diminish quickly or resolve with dose adjustment.
Does LDN help with chronic inflammation?
Yes. LDN modulates immune signaling that’s become dysregulated. It doesn’t suppress your immune system. Patients dealing with chronic inflammation, persistent fatigue, and inflammatory pain often report significant improvement. LDN works best as part of a comprehensive approach.
Can LDN be taken with other medications or therapies?
LDN is compatible with most medications. The exception is opioid-containing medications, which work in opposite ways. LDN is safe to combine with hormone therapy, peptides, GLP-1 medications, and other longevity treatments. We review your full medication list.
How long does it take for LDN to start working?
Some patients notice improvements within 7 to 10 days. Most experience meaningful benefits between 3 and 8 weeks. Full inflammation and pain modulation develop over 2 to 3 months. Consistency matters more than quick fixes.
Do I need labs before starting LDN?
No. Your symptoms and goals are sufficient to begin. If you want to track inflammatory markers objectively, our Complete Health Panel or Longevity Pro Panel includes relevant markers. Optional, not required.
Is LDN safe for long-term use?
Yes. Decades of clinical use suggest LDN is safe for ongoing use when properly dosed. It doesn’t strain the liver, cause dependence, or require escalating doses. Periodic check-ins ensure continued safety.
Why won’t my regular doctor prescribe LDN?
LDN is off-label for immune modulation. Most doctors weren’t taught about it. Insurance won’t cover it. Prescribing off-label requires extra documentation that busy practitioners avoid. The research exists, but mainstream medicine hasn’t caught up. We specialize in treatments that work, not just treatments that are easy to bill.
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The off-label treatment your doctor won’t prescribe.
Mainstream medicine waits for FDA approval that may never come. LDN has decades of clinical use, an understood mechanism, and an established safety profile. We prescribe what works, not just what’s easy to bill. Questions answered in 24 hours by providers who get it.
