NAD+ Injections

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell that’s essential for energy production. Your mitochondria need it to convert food into ATP, the energy currency your cells run on. It also activates sirtuins (longevity proteins), supports DNA repair, and maintains cellular function. Here’s the problem: levels drop roughly 50% by age 40. By 60, even lower. When NAD+ declines, cellular energy production suffers. The symptoms are predictable. Fatigue, brain fog, slow recovery, accelerated aging. Your doctor calls it “getting older.” We call it cellular energy depletion. And it’s fixable.

Oral NAD+ supplements have terrible bioavailability. Most of it is destroyed in digestion before reaching your cells. NAD+ precursors such as NMN or NR work slightly better because they’re smaller molecules that are converted to NAD+ inside cells. But it’s still an inefficient process. Injectable NAD+ bypasses digestion entirely. Direct to the bloodstream. Direct to cells. No conversion required. If you want NAD+ to reach your cells in meaningful amounts, injection is the only reliable method. The supplement industry won’t tell you this because they can’t sell you injections.

Most men notice an improvement in mental clarity within hours to days. Brain fog lifts, focus sharpens, and thinking speeds up. Physical energy typically improves within the first week. Recovery from exercise and exertion improves within 2-3 weeks. Mood and motivation often improve as fatigue lifts. Cognitive performance, better memory, and faster processing appear within 1-2 weeks. Anti-aging benefits (DNA repair, sirtuin activation) are cumulative over months. You won’t “feel” those immediately, but they’re happening at the cellular level. Results build with consistent use. This isn’t a one-and-done treatment.

Subcutaneous injection (similar to insulin) or intramuscular injection, typically 1-3 times per week depending on your protocol. Most men inject 0.5-1cc (100-200mg) per dose. Injections take about 30 seconds once you’re comfortable with the process. We provide injection training and dosing guidance.

Frequency depends on your goals. For acute needs, such as recovery from illness or intense physical demands, more frequent dosing helps. For general longevity and wellness maintenance, less frequent dosing suffices. Some men do intensive protocols for 4-8 weeks, then shift to maintenance. Others use it consistently long-term. We customize based on your response and goals.

NAD+ is generally well-tolerated. Possible effects include temporary flushing, mild nausea, lightheadedness, or brief fatigue after injection. Some men feel briefly overstimulated or jittery with higher doses. These effects are usually mild and temporary.

Starting with lower doses and gradually increasing minimizes side effects while your body adapts. IV infusions (not what we provide) often cause more pronounced side effects due to rapid administration. Subcutaneous or IM injection has gentler absorption. Most men tolerate NAD+ well once they find their optimal dose.

IV NAD+ infusions at clinics deliver higher doses over 1-4 hours. They work, but they’re expensive ($300-500+ per session) and require clinic visits. You’re paying for the IV setup, the clinic overhead, and the staff time to monitor you during infusion.

Our injectable NAD+ is self-administered at home, costs significantly less, and provides comparable cellular benefits with a gentler absorption profile. For most men pursuing general optimization, home-injectable NAD+ is more practical and sustainable in the long term. You’re not paying for a chair in someone’s clinic.

No. NAD+ doesn’t require baseline labs to start. Your symptoms and goals are enough to begin. However, if you want to track progress objectively, metabolic markers like fasting insulin, glucose, and inflammatory markers can be helpful. Our Complete Health or Longevity Pro panels include these markers for comprehensive baseline data.

Yes. NAD+ supports cellular function across all systems. It’s not competing with your other protocols. If you’re on TRT, Sermorelin, or other treatments, NAD+ ensures your cells have the energy to respond optimally. Many men add NAD+ to their existing protocols to enhance results.

Many men with chronic fatigue report significant improvements with NAD+ therapy. This makes sense because NAD+ directly supports mitochondrial energy production. If your fatigue stems from mitochondrial dysfunction or cellular energy deficits, restoring NAD+ levels addresses the root cause.

But chronic fatigue has many causes. Hormonal imbalance, nutrient deficiencies, inflammation, and autoimmune conditions. NAD+ alone won’t fix all of them. A comprehensive evaluation to identify contributing factors provides the best results. NAD+ therapy works best as part of a holistic approach rather than a standalone treatment. That’s why we look at the whole picture during your consultation.

Current evidence suggests NAD+ therapy is safe for long-term use when properly administered and monitored. NAD+ is a naturally occurring molecule essential for life. We’re restoring levels that decline with age, not introducing something foreign.

Long-term human studies are limited because NAD+ therapy is relatively new. But short-to-medium-term safety data is reassuring. Some people use NAD+ therapy regularly for years without adverse effects. The natural, physiologic role of NAD+ suggests favorable long-term safety compared to synthetic medications. As with any treatment, ongoing medical monitoring ensures continued safety and appropriateness.