Trimix
HSA/FSA Eligible ✓
When pills don’t work, this does. Trimix is a compounded injectable combining three vasodilators that work directly where they matter. It bypasses systemic circulation entirely, which is why it works for men who’ve failed on Viagra, Cialis, and everything else. Diabetes, nerve damage, post-surgery, and severe vascular issues. Trimix delivers when oral medications can’t.
85-90% effective. Even in severe ED, post-prostatectomy, and cases where every pill has failed.
Works in 5 to 15 minutes. Predictable timing. No waiting an hour and hoping.
We teach you proper technique. Injection training, dosing, safety protocols. Most men adapt faster than they expect.
Safety Information
Everything you need
What’s included with trimix
Safe, effective treatment shipped directly to your door.
Your treatment protocol
What to Expect:
Erections within 5 to 15 minutes of injection
Duration of 1 to 2 hours, depending on the dose
Mild discomfort at the injection site that fades quickly
Reliable results even when oral medications have completely failed
Includes:
5cc vial, customized strength based on your response†
Injection training and proper technique guidance
Dose titration to find your optimal level
Supplies and free shipping
†We start with a low test dose and titrate up based on your response. The goal is reliable 60- to 90-minute erections, not prolonged duration. Small dose changes make a big difference with Trimix.
See the difference
How our trimix compares
Most clinics hand you a vial and send you home. We teach proper technique, titrate your dose, and stay available to answer your questions.
Product Comparison
Industry Standard
Transparent pricing, no hidden fees
24-hour response guarantee
Injection training and technique guidance
Dose titration based on your response
Safety education and priapism protocols
Alternative options if Trimix isn’t right
Licensed physician oversight
The backup plan that works better
Why trimix works when pills don’t
Oral ED medications enhance your body’s natural response to stimulation. They need functioning blood flow and nerve signals to work. If those systems are compromised by diabetes, vascular disease, nerve damage, or surgery, pills fail. Trimix bypasses all of it. It works directly at the tissue level, causing vasodilation regardless of systemic conditions. That’s why it works for men who’ve tried everything else.
Injections aren’t as bad as you think
The needle is tiny, 29 to 31 gauge. Most men describe it as a slight pinch, less painful than a blood draw. The intimidation factor is worse than the reality. After a few uses, it becomes routine. The tradeoff is the reliability that pills can’t match.
Dosing matters
Trimix is potent. Small dose changes significantly affect response and duration. We start low and titrate carefully to find your optimal dose. Too little and it doesn’t work. Too much and you risk prolonged erection requiring medical intervention. Proper dosing is the difference between safe, reliable use and problems.
Simple. Fast. No runaround.
How trimix treatments work here
Three steps. Same-day appointments available.‡
1 Free Consult
Schedule a video call with one of our providers. We’ll discuss your symptoms, review your health history, and determine if treatment is right for you.
2 Treatment Plan
We finalize your protocol with transparent pricing. You’ll know exactly what you’re getting and what it costs before you commit to anything.
3 Ship Meds
Your medication ships discreetly with all supplies included. Ongoing provider appointments monitor your progress and adjust your protocol as needed.
‡Subject to provider availability
What trimix delivers when everything else fails
Specific outcomes. Realistic timelines. Based on what patients report.
Reliability you can count on
Trimix works consistently. No wondering if tonight’s the night the pill decides to work. Inject, wait 10 minutes, ready. That predictability changes everything for men who’ve been burned by inconsistent oral medications.
Timing you control
Works in 5 to 15 minutes. No planning an hour ahead. No waiting and hoping. You decide when, not your medication.
Duration that’s adjustable
Dose determines duration. We titrate to give you 60 to 90 minutes without risking prolonged erection. Enough time without the safety concerns of lasting too long.
Returned confidence
ED erodes confidence over time. Trimix restores it by delivering consistent results. Knowing it will work changes how you approach intimacy.
Works with other treatments
Combines with TRT for men whose low testosterone contributes to ED. Addresses the mechanical issue while hormones address the underlying drive.
Option when nothing else is
Post-prostatectomy. Severe diabetes. Spinal cord issues. Medication interactions that rule out oral options. Trimix works when the list of alternatives runs out.
Real patients. Real Results.
Why men choose TestDepot
Hear from men who’ve been where you are.
“Dr Spangler and his team have been outstanding. The process of appointments/follow-ups is convenient for your schedule and done in concise and timely fashion. Doc is very clear about identifying what works for your goals in the therapy. JD and the schedulers are diligent communicators and make the scheduling and medicine deliveries very easy.”
– Mike S
“Very smooth experience. Very good price. Appointments run on time and shipping is on time.”
– RJ
FAQ
Trimix questions answered
The questions most men ask before starting.
What is Trimix, and how is it different from ED pills?
Trimix is a compounded injectable medication containing three vasodilators: papaverine, phentolamine, and alprostadil (prostaglandin E1). Unlike oral PDE5 inhibitors like Viagra or Cialis, which enhance your body’s natural response to stimulation, Trimix works directly at the level of penile tissue to cause vasodilation and increased blood flow. It bypasses systemic factors like blood flow limitations, nerve damage, or medication interactions. This makes it highly effective when oral medications are ineffective or contraindicated.
How effective is Trimix?
Trimix has success rates exceeding 85 to 90% even in men with severe erectile dysfunction, diabetes, cardiovascular disease, nerve damage, or post-surgical ED from prostatectomy or radiation. It often works when all oral medications have failed. Effectiveness is dose-dependent and highly individualized. We titrate your dose to provide reliable 1 to 2-hour erections with minimal side effects. Many men frustrated by failed oral medications find that Trimix reliably delivers results.
How do I inject Trimix?
Trimix is injected into the corpus cavernosum (spongy erectile tissue) on the side of the penis using a very small needle, typically 29 to 31 gauge. Injection sites should be alternated and rotated to prevent scar tissue formation. We provide detailed instructions on proper technique, site selection, and safety protocols. Most men find the injection process much less intimidating than expected. The needles are tiny, and with proper technique, discomfort is minimal.
What are the risks of Trimix?
The most serious risk is priapism, an erection lasting over 4 hours that requires immediate medical attention to prevent permanent damage. This is rare with proper dosing, but it is a medical emergency if it occurs. Other risks include pain or bruising at injection sites, scar tissue formation with frequent long-term use, minor bleeding, or infection with poor technique. These risks are minimized through proper dosing, good technique, site rotation, and following medical guidance. Most men use Trimix safely for years.
How long does the erection from Trimix last?
Trimix typically produces erections lasting 1 to 2 hours, though this is dose-dependent. Lower doses may provide 45 to 60 minutes of relief, while higher doses can last over 2 hours. The goal is to find your optimal dose that provides adequate duration, typically 60 to 90 minutes, without prolonged erection. If erections consistently last under 30 minutes, the dosage may need to be increased. If regularly exceeding 2 hours, the dosage should be reduced. We titrate carefully for optimal duration and safety.
How quickly does Trimix work?
Trimix typically produces erections within 5 to 15 minutes of injection, with full effect apparent within 10 to 20 minutes. This rapid onset is one of Trimix’s advantages. Unlike oral medications requiring 30 to 60 minutes’ notice, Trimix allows shorter notice. However, the rapid onset also means proper dosing is critical. There’s less room for error than with oral medications that have a gradual onset.
Can I adjust my Trimix dose?
Dose adjustments should be made only under a physician’s guidance. Trimix is very potent, and small dose changes can significantly affect response and risk of priapism. We start with a low test dose and carefully titrate upward based on your response. Once your optimal dose is determined, stick with it consistently. If you notice changes in effectiveness, contact us for guidance on dose adjustments rather than self-adjusting.
Does the injection hurt?
Less than most men expect. The needle is very small, 29 to 31 gauge, similar to the size of insulin syringes. Most men describe it as a slight pinch or pressure. Proper technique minimizes discomfort. After a few uses, most men report that the injection becomes routine and barely noticeable. The anticipation is typically worse than the reality. We teach proper technique to ensure minimal discomfort.
How should I store Trimix?
Trimix must be refrigerated at 36 to 46°F and typically remains stable for 30 to 60 days after compounding, depending on formulation. Never freeze Trimix. Before each use, allow it to reach room temperature or inject it cold, depending on your preference. Keep it out of light in its original container. Mark your vial with the date received and discard after expiration. If Trimix changes color or develops particles, don’t use it.
What is priapism, and what do I do if it happens?
Priapism is an erection lasting longer than 4 hours. It’s a medical emergency because prolonged erection without blood flow cycling can cause permanent tissue damage and erectile dysfunction. If your erection lasts longer than 4 hours, go to an emergency room immediately. Treatment typically involves draining blood from the penis and/or injecting medication to reverse the erection. Proper dosing makes priapism rare, but knowing the signs and response is critical for safe Trimix use.
Can Trimix cause permanent damage?
When used properly with correct dosing and technique, Trimix is safe for long-term use. However, improper use can cause complications. Priapism, if untreated, can cause permanent erectile tissue damage. Repeated injections in the same site can cause scar tissue, affecting erectile function. Poor technique can cause bleeding or nerve damage. These risks are minimized through proper training, site rotation, appropriate dosing, and following medical guidelines.
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When the pills fail, Trimix works
Injectable ED treatment with 85 to 90% effectiveness, even in severe cases. Works in minutes, not an hour. We teach proper technique, titrate your dose, and stay available to answer your questions. No more hoping tonight’s the night the pill decides to work. Questions answered in 24 hours by providers who understand when the standard options aren’t enough.
