VIP Peptide

VIP (Vasoactive Intestinal Peptide) is a naturally occurring neuropeptide your body produces in the brain, gut, lungs, and immune system. It plays a critical role in regulating inflammation, blood flow, immune balance, and communication between your nervous and immune systems. When VIP levels drop or receptors become desensitized, you lose a critical brake pedal on inflammatory response. Everything gets louder. Recovery gets harder. Restoring VIP helps your body remember how to calm itself down.

VIP peptide delivered intranasally absorbs through the nasal lining directly into your bloodstream and central nervous system. This bypasses digestion, which would break down the peptide before it could work. Nasal delivery provides rapid access to the brain and systemic circulation. Once absorbed, VIP binds to receptors throughout your body, particularly in the lungs, gut, and immune cells, helping regulate inflammation and restore proper immune signaling. Many patients notice a subtle calming or focusing effect due to VIP’s neuroregulatory properties.

Results vary depending on individual biology and goals. Most patients notice improved mental clarity and a calmer nervous system within 1 to 2 weeks. Gut symptoms, food sensitivities, and inflammatory flares typically improve over 4 to 8 weeks. Energy regulation and environmental tolerance build gradually with consistent use. Because VIP works through modulation rather than stimulation, benefits accumulate over time and stabilize rather than hitting all at once.

The typical protocol starts with 4 sprays daily, alternating nostrils with each spray, for 30 days. After the initial loading phase, most patients reduce to 1 to 2 sprays daily for maintenance. Some patients do well with every-other-day dosing depending on sensitivity and response. Duration of therapy varies. Some use it for short-term support during periods of stress or recovery, while others benefit from longer-term use under medical supervision. We customize dosing to your response, not a standard protocol we hand everyone.

VIP peptide therapy is generally well tolerated. Some patients experience mild nasal irritation, brief flushing, warmth, or temporary lightheadedness after a dose. Because VIP affects blood flow, occasional users may experience sinus openness shortly after administration. Rarely, some may feel overstimulated or fatigued, depending on dose sensitivity. Most side effects diminish within the first week or resolve with dose adjustment. Starting low and gradually increasing helps ensure comfort.

VIP is known for its role in balancing the immune system and reducing inflammatory overactivation. It helps shift immune signaling toward a more regulated pattern, which may improve tolerance to foods, environments, and substances that previously caused problems. VIP addresses the immune dysregulation driving the sensitivity, not just the symptoms. Optimal results often occur when VIP is part of a broader, personalized health strategy addressing root causes.

VIP combines safely with hormone therapy, other peptides, GLP-1 medications, and most longevity protocols. Because chronic inflammation interferes with the effectiveness of other treatments, VIP often improves outcomes from the therapies you’re already using. Many patients stack VIP with TRT, Sermorelin, or LDN for compounding benefits. We review your full medication list and treatment history to ensure compatibility and optimize your protocol.

Some patients feel benefits such as improved mental clarity, calmer breathing, or reduced inflammatory reactivity within the first few doses, often within hours to days. More substantial regulatory effects, including improved resilience, more stable energy, and better immune balance, typically develop over 4 to 8 weeks of consistent use. Full inflammation and immune modulation may take 2 to 3 months. Consistency matters more than quick fixes.

No. Your symptoms and clinical history are sufficient to begin. If you want to track inflammatory markers objectively, our Complete Health Panel or Longevity Pro Panel includes relevant markers like CRP and homocysteine. This gives you a baseline to measure progress if you prefer data-driven confirmation. Optional, not required.

Current clinical experience suggests VIP peptide therapy is safe for ongoing use when properly dosed and medically supervised. As a naturally occurring neuropeptide, VIP works within your body’s existing regulatory systems rather than overriding them. It doesn’t strain the liver, cause dependence, or require escalating doses. Long-term therapy may be appropriate for those needing ongoing immune or neurologic support. Periodic check-ins ensure continued safety and appropriate dosing.

VIP peptide nasal spray should be kept refrigerated to preserve peptide stability. It can be left at room temperature for short periods during daily use or travel, but should be returned to the refrigerator afterward. Avoid leaving it in hot environments such as cars or direct sunlight, as heat degrades peptides and reduces effectiveness.

VIP is off-label for inflammatory and gut conditions. Most doctors weren’t taught about it in medical school. Insurance won’t cover it. Prescribing off-label requires extra documentation and follow-up that busy practitioners avoid. The functional medicine community has used VIP successfully for over a decade. The research exists. The clinical experience exists. Mainstream medicine just hasn’t caught up. We specialize in treatments that work, not just treatments that are easy to bill.